E-viri
Recenzirano
Odprti dostop
-
Noorani, Ayesha; Li, Xiaodun; Goddard, Martin; Crawte, Jason; Alexandrov, Ludmil B; Secrier, Maria; Eldridge, Matthew D; Bower, Lawrence; Weaver, Jamie; Lao-Sirieix, Pierre; Martincorena, Inigo; Debiram-Beecham, Irene; Grehan, Nicola; MacRae, Shona; Malhotra, Shalini; Miremadi, Ahmad; Thomas, Tabitha; Galbraith, Sarah; Petersen, Lorraine; Preston, Stephen D; Gilligan, David; Hindmarsh, Andrew; Hardwick, Richard H; Stratton, Michael R; Wedge, David C; Fitzgerald, Rebecca C
Nature genetics, 01/2020, Letnik: 52, Številka: 1Journal Article
The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individuals with EAC showed, in 90% of patients, that multiple subclones from the primary tumor spread very rapidly from the primary site to form multiple metastases, including lymph nodes and distant tissues-a mode of dissemination that we term 'clonal diaspora'. Metastatic subclones at autopsy were present in tissue and blood samples from earlier time points. These findings have implications for our understanding and clinical evaluation of EAC.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.