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Sarmiento-Sánchez, Juan I.; Montes-Avila, Julio; Ochoa-Terán, Adrián; Delgado-Vargas, Francisco; Wilson-Corral, Victor; Díaz-Camacho, Sylvia P.; García-Páez, Fernando; Bastidas-Bastidas, Pedro
Química Nova, 2014, Letnik: 37, Številka: 8Journal Article
A facile one-step synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides and TMSA was described. This paper determines their antimicrobial activity against nine human bacterial pathogens by the broth microdilution method; antioxidant activity by DPPH• inactivation and a ferric-reducing power assay; and toxicity by a brine shrimp, Artemia salina, assay. The 1H-benzoxazine-2,4-dione yields were in the range of 57 to 98%. The novel compound 1H-pyrazino2,3-1,3oxazine-2,4-dione 4c showed the highest antioxidant capacity (DPPH 35.4% and FRAP 0.063 µmol TEs/µmol).
