The WFPC2 was installed in the Hubble Space Telescope (HST) in 1993 December. Since then, the instrument has been providing high-quality images. A significant amount of calibration data has been collected to aid in the understanding of the on-orbit performance of the instrument. Generally, the behavior of the camera is similar to its performance during the system-level thermal vacuum test at JPL in 1993 May. Surprises were a significant charge-transfer-efficiency (CTE) problem and a significant growth rate in hot pixels at the original operating temperature of the CCDs (– 76 °C). The operating temperature of the WFPC2 CCDs was changed to –88 °C on 1994 April 23, and significant improvements in CTE and hot pixels are seen at this temperature. In this paper we describe the on-orbit performance of the WFPC2. We discuss the optical and thermal history, the instrument throughput and stability, the PSF, the effects of undersampling on photometry, the properties of cosmic rays observed on-orbit, and the geometric distortion in the camera. We present the best techniques for the reduction of WFPC2 data, and describe the construction of calibration products including superbiases, superdarks, and flat fields.