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Muir, W J; Squire, I; Blackwood, D H; Speight, M D; St Clair, D M; Oliver, C; Dickens, P
Journal of mental deficiency research, 12/1988, Letnik: 32 ( Pt 6)Journal Article
Sixty-five subjects with Down's syndrome were followed up and retested 2 years after the initial recording of auditory P300 (P3) event-related potential described in a companion paper (Blackwood et al., 1988). The number of subjects showing clinical evidence for Alzheimer's type dementia had increased by a further 14%. In subjects showing clinical deterioration over a period of 2 years, 78% (7/9) had an increase in P3 latency which was three standard deviations or greater than the group mean. None of the 20 fragile-X group retested showed significant change after 2 years. The results suggest that P3 change may be a sensitive index of the onset of Alzheimer's type dementia in Down's syndrome.
