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Trigg, M E; Billing, R; Sondel, P M; Dickerman, J D; Erickson, C; Finlay, J L; Bozdech, M; Hong, R; Padilla-Nash, H; Terasaki, P
Journal of biological response modifiers 3, Številka: 4Journal Article
CT-2 mouse monoclonal antibody to the E-rosette receptor was used with complement to deplete bone marrow of E-rosette-positive cells (T cells). Depletion of E-rosette-positive cells was complete and nontoxic to hematopoietic progenitor cells. Depletion of E-rosette-positive cells with CT-2 may decrease the severity of graft-versus-host disease following bone marrow transplantation and extend the application of bone marrow transplantation to those without HLA-identical donors.
