Background & aim: As one of the most influential factors of marital life, sexual satisfaction can significantly lead to peace and compatibility of couples. The present study investigated the effect of Guided Imagery and Music (GIM) on the level of sexual satisfaction in women of reproductive age.Methods: In this parallel cluster-randomized trial which was conducted from Feb. 2019 to Apr. 2020, 72 women of reproductive age (two groups of 36 subjects) who had moderate or undesirable sexual satisfaction were sampled. The guided imagery music was presented for the intervention group for 6 weeks as twice a week. No intervention was performed for the control group.  The data collection tool included fertility characteristics and Larson questionnaires, which was completed before, immediately and one month after the intervention. Data were analyzed by SPSS software (version 20) using independent t-test, chi-square, Mann-Whitney and variance analysis with repeated measurements.Results:  There was no statistically significant difference between the two groups in the sexual satisfaction score before the intervention. The mean sexual satisfaction score in the intervention group had a statistically significant difference between the baseline (91.1±9.1), immediately after intervention (112±4.46) and one month later (102±9.24) (P< 0.001). However, there was no significant difference between the changes in the sexual satisfaction of women in the control group between three times.Conclusion: GIM technique improves women's sexual satisfaction. It is recommended to health care providers to use this behavioral technique to enhance the level of sexual satisfaction in women of reproductive age.