The increase in complexity of electronic systems has opened the way to the use of different types of operating systems working together. The development of these systems requires simulation infrastructures where the entire system, including all its OSs, can be simulated, both for functional verification and performance evaluation. However, the generation of such simulation infrastructures with current technologies usually requires a huge effort that high-level engineers cannot support. In order to solve this problem, the paper presents a solution for simulating systems composed of different kinds of OSs. The approach is based on native simulation and presents an example combining Linux and Win32 systems in a single simulation. This example ensures usability since these are two of the most complex OSs commonly integrated in electronic devices. Nevertheless, the idea can also be extended to support other OSs. As a result, engineers can take advantage of an infrastructure capable of modeling complex architectures with different operating systems requiring relatively little design effort, for early system evaluation at the beginning of the design process.