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Takahashi, Hideyuki; Strittmatter, Stephen M
Nature (London), 05/2022, Letnik: 605, Številka: 7909Journal Article
...the three studies found fibrils derived from individuals who have a common, disease-protective variant of TMEM106B, as well as fibrils without that variant, indicating that the variant itself is not directly responsible for the propensity of TMEM106B to form fibrils. ...the cryo-electron-microscopy structures reveal evidence of a small molecule bound to TMEM106B, the identity of which remains unknown. ...TDP-43 fibrils were not observed in these studies.
