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Marijana Krsnik-Rasol; Biljana Balen
Food technology and biotechnology, 01/2007, Letnik: 45, Številka: 1Journal Article
Transgenic plants have recently emerged as a promising system for low-cost and large-scale production of therapeutic proteins. Despite many advantages plants offer as hosts for expression of recombinant proteins, there are certain limitations caused by major structural differences between plant and mammalian N-linked glycans. Thus, efforts are being made in order to eliminate, or at least minimize, plant-specific N-glycosylation as well as to supplement the plant endogenous system with human glycosyltransferases to obtain »humanized« non-immunogenic N-glycans on plant-made pharmaceuticals aimed for human therapy.
