During the tour, tourist guides, who act as a bridge between visitors and local people, have many roles for tourists. One of the important roles among these roles is the interpretive role. Rather than providing information directly, it has a great effect of presenting the information to the tourists after making it understandable. At this point, it is a question of whether tourists have an impact on destination loyalty, based on the interpretive role of tourist guides. The purpose of thisstudy is to reveal the effect of the interpretative role of tourist guides on tourist destination loyalty and to determine the mediating role of the concept of satisfaction, which can be a result of the feeling of pleasant feelings during the tour. Accordingly, the data were collected from 391 guests who toured the Çanakkale Wars Gallipoli Historical Site, which constitutes the research area,with a guide. In the light of the data obtained from the survey participants, it was concluded that the interpretative role of tourist guides was effective on tourist destination loyalty. It has been determined that tourist satisfaction also plays a mediating role in this effect.