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  • Effects of amitriptyline, d...
    Linnoila, M; Johnson, J; Dubyoski, T; Ross, R; Buchsbaum, M; Potter, W Z; Weingartner, H

    Acta psychiatrica Scandinavica. Supplementum, 1983, Letnik: 308
    Journal Article

    Interactions of three antidepressants--amitriptyline, desipramine and zimeldine--with a single 0.8 g/kg body weight dose of alcohol were studied in healthy male volunteers. The dependent variables were performance measurements in the Continuous Performance Task and a cognitive memory task. Alcohol and desipramine showed different and specific deleterious effects on cognitive and memory functions, whereas amitriptyline produced a more generalized impairment. Zimeldine slightly improved performance in the Continuous Performance Task and antagonized effects of alcohol in both tasks.