Display omitted •The Paleocene high-silica granites originated from the juvenile lower crust.•Fractional crystallization significantly affects the formation of high-silica granite.•The crust-mantle magma mixing plays an important role in the crustal reworking. The history of crustal growth in the western Central Lhasa (CL) subterranean during India-Eurasian collision remains unclear. The crucial problem is lack of suitable and ideal magmatism recorded information of the early stages of continental collision. Here, we report the newly discovered high-silica granites (K-feldspar granite with aplite granite) hosting diorite enclaves from the Geji area in western CL subterrane. This suite of magmatic rocks is of great significance to reveal the crustal growth of CL during the India-Eurasia collision. Zircon U-Pb dating results show that the K-feldspar granite, aplite granite, and diorite enclaves were formed at 57.2–57.9 Ma, 58.7 Ma and 58.2 Ma, respectively. Petrology, mineralogy, and mineral chemistry of the plagioclase from the diorite enclave indicates that it was generated by magma mixing between mafic and felsic magmas. The mafic melt was sourced from partial melting of mantle wedge and metasomatized by subduction fluid and sediment melt. This has been supported by the positive zircon εHf(t) values (+0.6 to + 4.9), enrichment of large ion lithophile elements (Rb, K, Th, and U) and depletion of high field strength elements (Nb and Ta), and the high Th/Ce ratios of diorite enclaves. The K-feldspar granite also has positive zircon εHf(t) values (+1.3 to +6.2), arc magma geochemical features, and a lower crust Nb/Ta ratio (8.3). These indicate that the K-feldspar granite was originated from the juvenile lower crust. In conclusion, we think that the crust-mantle magma mixing has a substantial impact on the crustal growth of the western CL subterrane during the subduction slab roll-back of the Paleocene Neo-Tethys Ocean when paired with other research and the context of regional tectonic development.