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Stereodivergent Construction of Contiguous Quaternary Carbon Centers Enabled by Asymmetric CatalysisHuo, Jiyou; Li, Xiuhuan; Chen, Qianhu; Gao, Pengpeng; Hou, Yi; Lei, Pan; Zou, Huanhuan; Yan, Jiahang; Wan, Xiaolong; Xie, Weiqing
ACS catalysis, 11/2023, Letnik: 13, Številka: 22Journal Article
Herein, we report the discovery of the catalytic asymmetric conjugated addition of allylstannanes to indol-2-ones promoted by Ni(II)/chiral N,N′-dioxide. This method enables the stereodivergent construction of contiguous quaternary carbon centers (CQCCs), which can be readily achieved by a suitable combination of a chiral catalyst with stereospecific allylstannanes. This protocol allows for a unified access to all stereoisomers of 3,3-disubstituted oxindoles with CQCCs in good to excellent enantioselectivities and diastereoselectivities.
