The activity of many physiological mechanisms depends on pH; therefore, maintaining a normal pH in the body is one of the important tasks of homeostatic regulation. Shifts in the acid–base balance can be associated with both pathological and physiological processes. Physiological acidosis in skeletal muscles appears due to physical exercise as muscle contractions may significantly reduce pH in muscle fibers and interstitium. However, after the cessation of contractions, the pH level rapidly normalizes, which is largely ensured by the work of the circulatory system, which removes metabolic products from the muscle. Acidosis causes vasodilatation by affecting the activities of numerous mechanisms in smooth muscle and endothelial cells and by inhibiting vasoconstrictor nerve influence. Vasodilation and increased muscle blood flow are favorable to recovery of the skeletal muscle performance following intense contractions.