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Fenoglio, Chiara; Ridolfi, Elisa; Cantoni, Claudia; De Riz, Milena; Bonsi, Rossana; Serpente, Maria; Villa, Chiara; Pietroboni, Anna M; Naismith, Robert T; Alvarez, Enrique; Parks, Becky J; Bresolin, Nereo; Cross, Anne H; Piccio, Laura M; Galimberti, Daniela; Scarpini, Elio
Multiple sclerosis, 12/2013, Letnik: 19, Številka: 14Journal Article
Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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