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Toffoli, Marco; Smith, Laura; Schapira, Anthony H. V.
Journal of neurochemistry, July 2020, 2020-07-00, 20200701, Letnik: 154, Številka: 1Journal Article
The discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) constitutes an important milestone in understanding this disorder's pathophysiology and potential treatment. Among these genes, GBA1 is one of the most common and well‐studied, but it is still unclear how mutations in GBA1 translate into an increased risk for developing PD. In this review, we provide an overview of the biochemical and structural relationship between GBA1 and PD to help understand the recent advances in the development of PD therapies intended to target this pathway. The discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) constitutes an important milestone in understanding its pathopysiology and potential treatment. Among these genes, GBA1 is one of the most common and well‐studied, but it is still unclear how mutations in GBA1 can translate into an increased risk of developing PD. In this review, we analyzed the literature and tried to give a comprehensive overview of the biochemical and structural relationship between GBA1 and PD to better understand the recent advancements in the therapy of PD.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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