Studies of coral colonies show that ocean acidification and temperature can affect calcification; however, less is known about the consequences for their populations. Understanding intraspecific variation in the response of corals to these conditions will be important for evaluating population-level consequences of environmental change. We examined intraspecific variability in the effects of elevated temperature and carbon dioxide levels on net calcification ( G n ) in the coral Acropora pulchra in Moorea, French Polynesia. A common garden experiment showed that G n in four colonies was affected negatively by high partial pressure of CO 2 (pCO 2 ) (~1000 μatm cf. ~400 μatm ambient conditions), whereas elevated temperature (30 °C cf. 27 °C) had a negative effect on one colony. Together, these results reveal intraspecific variation in the response of G n to temperature but not to pCO 2 . The fastest growing colonies under ambient temperature and ambient pCO 2 showed the greatest decline in G n at high temperature and elevated pCO 2 . For reef corals, effects of temperature and pCO 2 on calcification that depend on the intrinsic growth rate have potentially important consequences, because they imply that coral colonies contributing the most to population-level calcification will be disproportionately affected by changing environmental conditions.