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Laru, Sudip; Bhattacharjee, Suvam; Singsardar, Mukta; Samanta, Sadhanendu; Hajra, Alakananda
Journal of organic chemistry, 02/2021, Letnik: 86, Številka: 3Journal Article
A Ru(II)-catalyzed facile and controllable protocol for C–H alkylation and spirocyclization of 2-arylquinoxalines with maleimides has been achieved under ambient air in high yields. Sequential ortho-C–H activation and C-annulation results in the formation of diverse polyheterocycles containing spiroindeno1,2-bquinoxaline-11,3′-pyrrolidine-2′,5′-diones, which are of potent interest in medicinal chemistry. Mechanistic investigations suggest a reversible cleavage of the ortho-C–H bond in the turnover-limiting step.
