E-viri
Recenzirano
-
Bogdanova, Natalia; Togo, Alexandr V.; Ratajska, Magdalena; Kluźniak, Wojtek; Takhirova, Zalina; Tarp, Theresa; Prokofyeva, Darya; Bermisheva, Marina; Yanus, Grigoriy A.; Gorodnova, Tatiana V.; Sokolenko, Anna P.; Kuźniacka, Alina; Podolak, Amira; Stukan, Maciej; Wokołorczyk, Dominika; Gronwald, Jacek; Vasilevska, Danuta; Rudaitis, Vilius; Runnebaum, Ingo B.; Dürst, Matthias; Park-Simon, Tjoung-Won; Hillemanns, Peter; Antonenkova, Natalia; Khusnutdinova, Elza; Limon, Janusz; Lubinski, Jan; Cybulski, Cezary; Imyanitov, Evgeny; Dörk, Thilo
Familial cancer, 03/2015, Letnik: 14, Številka: 1Journal Article
A nonsense mutation, p.Q548X, in the BLM gene has recently been associated with an increased risk for breast cancer. In the present work, we investigated the prevalence of this Slavic founder mutation in 2,561 ovarian cancer cases from Russia, Belarus, Poland, Lithuania or Germany and compared its frequency with 6,205 ethnically matched healthy female controls. The p.Q548X allele was present in nine ovarian cancer patients of Slavic ancestry (0.5 %; including one case with concurrent BRCA1 mutation). The mutation was not significantly more frequent in cases than in controls (Mantel–Haenszel OR 1.14, 95 % CI 0.49; 2.67). Ovarian tumours in p.Q548X carriers were mainly of the serous subtype, and there was little evidence for an early age at diagnosis or pronounced family history of cancer. These findings indicate that the BLM p.Q548X mutation is not a strong risk factor for ovarian cancer.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.