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Wang, Shirley V.; Lin, Kueiyu Joshua; Schneeweiss, Sebastian
Pharmacoepidemiology and drug safety, 20/May , Letnik: 33, Številka: 5Journal Article
Direct oral anticoagulants (DOACs) revolutionized the management of thromboembolic disorders. Clinical care may be further improved as Factor XIs undergo large‐scale outcome trials. What role can non‐randomized database studies play in expediting understanding of these drugs in clinical practice? The RCT‐DUPLICATIVE Initiative emulated the design of eight DOAC randomized clinical trials (RCT) using non‐randomized claims database studies. RCT study design parameters and measurements were closely emulated by the database studies and produced highly concordant results. The results of the single database study that did not meet all agreement metrics with the specific RCT it was emulating were aligned with a meta‐analysis of six trials studying similar questions, suggesting the trial result was an outlier. Well‐designed database studies using fit‐for‐purpose data came to the same conclusions as DOAC trials, illustrating how database studies could complement RCTs for Factor XI inhibitors—by accelerating insights in underrepresented populations, demonstrating effectiveness and safety in clinical practice, and testing broader indications.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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