E-viri
Recenzirano
-
Martínez, Cristina; Moreno, Santiago; Dalmau, David; García, Federico; Iribarren, José Antonio; Rubio, Rafael; González, Juan; Muñoz‐Fernández, M Ángeles; Iniesta, Carlos; Muñoz‐Fernández, M Ángeles; Sánchez‐Payá, José; Rodríguez, Juan Carlos; López Lirola, Ana; García, Dácil; Hernández, María Inmaculada; Domínguez, Lourdes; Rial Crestelo, David; Bermejo, Laura; Santacreu, Mireia; Aramburu, María José; Goenaga, Miguel Ángel; Colomé, Joan Gregori; Pascual, Rafael; Agullo Re, Vanessa; García Abellán, Javier; Gutiérrez, Isabel; Ramírez, Margarita; Padilla, Belén; Aldamiz‐Echevarría, Teresa; Olona, Montserrat; Rull, Anna; Rodríguez‐Gallego, Esther; López‐Dupla, Miguel; Montero Alonso, Marta; Tasias Pitarch, María; Calabuig Muñoz, Eva; Fernández Navarro, Juan; Arnalich, Francisco; Arribas, José Ramón; Herranz, Pedro; Esteban Micán, Rafael; Montes, María Luisa; Pérez‐Valero, Ignacio; Blanco, José Ramón; Ibarra, Valvanera; Metola, Luis; Arazo, Piedad; Sampériz, Gloria; Dalmau, David; Sanmartí, Montse; Martinez‐Lacasa, Javier; Aiello, Francesco; Gracia Ruiz de Alda, María; Amengual, María José; Cervantes García, Manel; Calzado Isbert, Sonia; Navarro Vilasaro, Marta; Sarria Cepeda, Cristina; Casado Osorio, José Luis; Dronda Núñez, Fernando; Pérez Elías, Maria Jesús; Vivancos Gallego, María Jesús; Martínez Sanz, Javier; Alcaraz, María Jose; Villalba, María del Carmen; Muñoz Medina, Leopoldo; Chueca, Natalia; Martínez‐Montes, Clara; Guerrero Beltrán, Carlos; Rodríguez, Carmen; Puerta, Teresa; Murillas, Javier; Vilchez, Helem H; Martin, Maria Luisa; Payeras, Antoni; Gonzalez‐Domenec, Carmen Maria; Silva, Ana; Ribera, Esteban; Olalla Sierra, Julián; Prada, José Luis; García de Lomas Guerrero, José María; Castro Iglesias, Ángeles; Baraia‐Etxaburu, Josu Mirena; Ferrero Beneitez, Oscar Luis; Lopez, Miriam; Galera, Carlos; Albendin, Helena; Merlos, María Angustias; Vidal, Asunción; Amador, Concha; Ena, Javier; Martín Rodrigo, Dolores; Mohamed‐Balghata, Mohamed Omar; Pérez‐Somarriba Moreno, Juncal; Górgolas, Miguel; Cabello, Alfonso; Sanz Moreno, José; Frias Casas, Mario; Pérez, Alexandre; Ocampo, Antonio
HIV medicine, September 2022, Letnik: 23, Številka: 8Journal Article
Objectives To pinpoint factors associated with low‐level viraemia (LLV) and virological failure (VF) in people living with HIV in the era of high‐efficacy antiretroviral treatment (ART) and widespread use of integrase strand transfer inhibitor (INSTIs)‐based ART. Methods We included adults aged > 18 years starting their first ART between 2015 and 2018 in the Spanish HIV/AIDS Research Network National Cohort (CoRIS). Low‐level viraemia was defined as plasma viral load (pVL) of 50–199 copies/mL at weeks 48 and 72 and VF was defined as pVL ≥ 50 copies/mL at week 48 and pVL ≥ 200 copies/mL at week 72. Multivariable logistic regression models assessed the impact on LLV and VF of baseline CD4 T‐cell count, CD4/CD8 T‐cell ratio and pVL, initial ART classes, age at ART initiation, time between HIV diagnosis and ART initiation, gender and transmission route. Results Out of 4186 participants, 3120 (76.0%) started INSTIs, 455 (11.1%) started boosted protease inhibitors (bPIs) and 443 (10.8%) started nonnucleoside reverse transcriptase inhibitors (NNRTIs), either of them with two nucleos(t)ide reverse transcriptase inhibitors (NRTIs). Low‐level viraemia was met in 2.5% of participants and VF in 4.3%. There were no significant differences throughout the years for both virological outcomes. Baseline HIV‐1 RNA > 5 log10 copies/mL was the only consistent predictor of higher risk of LLV adjusted odds ratio (aOR) = 9.8, 95% confidence interval (CI): 2.0–48.3 and VF (aOR = 5.4, 95% CI: 1.9–15.1), even in participants treated with INSTIs. Conclusions The rates of LLV and VF were low but remained steady throughout the years. Baseline HIV‐1 RNA > 5 log10 copies/mL showed a persistent association with LLV and VF even in participants receiving INSTIs.
