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  • Long‐term evolutionary adap...
    Schmitt, Kimberly; Curlin, James; Remling‐Mulder, Leila; Morrison, Jared; Moriarty, Ryan; Goff, Kelly; Stenglein, Mark; O'Connor, Shelby; Marx, Preston; Akkina, Ramesh

    Journal of medical primatology, October 2022, 2022-10-00, 20221001, Letnik: 51, Številka: 5
    Journal Article

    Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV‐1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV‐1 Group M over the course of four generations. Higher initial viral load, increased CD4+ T‐cell decline, and nonsynonymous substitutions arose suggesting viral evolution.