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Lemmens, Valery E.; Klaver, Yvonne L.; Verwaal, Vic J.; Rutten, Harm J.; Coebergh, Jan Willem W.; de Hingh, Ignace H.
International journal of cancer, 1 June 2011, Letnik: 128, Številka: 11Journal Article
The aim of our study was to provide population‐based data on incidence and prognosis of synchronous peritoneal carcinomatosis and to evaluate predictors for its development. Diagnosed in 1995–2008, 18,738 cases of primary colorectal cancer were included. Predictors of peritoneal carcinomatosis were analysed by multivariable logistic regression analysis. Median survival in months was calculated by site of metastasis. In the study period, 904 patients were diagnosed with synchronous peritoneal carcinomatosis (4.8% of total, constituting 24% of patients presenting with M1 disease). The risk of peritoneal carcinomatosis was increased in case of advanced T stage T4 vs. T1,2: odds ratio (OR) 4.7, confidence limits 4.0–5.6), advanced N stage N0 vs. N1,2: OR 0.2 (0.1–0.2), poor differentiation grade OR 2.1 (1.8–2.5), younger age <60 years vs. 70–79 years: OR 1.4 (1.1–1.7), mucinous adenocarcinoma OR 2.0 (1.6–2.4) and right‐sided localisation of primary tumour left vs. right: OR 0.6 (0.5–0.7). Median survival of patients with peritoneum as single site of metastasis remained dismal 1995–2001: 7 (6–9) months; 2002–2008: 8 (6–11) months, contrasting the improvement among patients with liver metastases 1995–2001: 8 (7–9) months; 2002–2008: 12 (11–14) months. To conclude, synchronous peritoneal metastases from colorectal cancer are more frequent among younger patients and among patients with advanced T stage, mucinous adenocarcinoma, right‐sided tumours and tumours that are poorly differentiated. The prognosis of synchronous peritoneal carcinomatosis remains poor with a median survival of 8 months and even worse if concomitant metastases in other organs are present.
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in: SICRIS
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