E-viri
Recenzirano
-
Shen, Yu J.; Ho, Samantha S.W.; Tan, Nikki Y.; Koo, Christine Xing’Er; Khatoo, Muznah; Cheung, Florence S.G.; Gasser, Stephan
Cytokine (Philadelphia, Pa.), 12/2015, Letnik: 76, Številka: 2Journal Article
•Genome-derived ssDNA, dsDNA and DNA:RNA hybrids are present in the cytosol of tumor cells.•Cytosolic DNA can potentially form non-B DNA structures.•Cytosolic DNA contributes to type I interferon-dependent immune rejection of B-cell lymphoma. We recently provided evidence that genome-derived DNA is present in the cytosol of many tumor cells. Genomic loci that give rise to cytosolic DNA can potentially form non-B DNA structures including triple-stranded RNA:DNA structures (R-loops). The RNA:DNA-specific endonuclease RNaseh1 reduced the levels of cytosolic DNA and type I interferon-dependent rejection of B-cell lymphoma suggesting that cytosolic DNA may contribute to immune surveillance of B-cell lymphoma.
