The following examines factors associated with Indigenous secondary student success with a focus on wise practices in quality education in a northern Ontario city, Canada. Wise practices are an Indigenous perspective on best practices that recognizes there are a diversity of Indigenous ways of knowing and being, and that local histories, communities, and cultural practices are relevant. Results of qualitative research with Indigenous students, staff, teachers, and graduates suggest that parents and the social environment are determinants in Indigenous student success and that Indigenous students negotiate their identity in the pursuit of success. Furthermore, Indigenous curriculum and Indigenous teachers and administrative staff are essential in supporting student success and nurturing the educational journeys of students. Wise practices in Indigenous education in northern Ontario reflect localized land-based learning and teaching in collaboration with urban Indigenous organizations and Elders, and Knowledge holders and administrative officials.