This investigation reports application of a mesoporous nanomaterial based on dicationic ionic liquid bonded to amorphous silica, namely nano- N , N , N ′, N ′-tetramethyl- N -(silica n -propyl)- N ′-sulfo-ethane-1,2-diaminium chloride (nano-TSPSEDCl 2 ), as an extremely effectual and recoverable catalyst for the generation of bis(pyrazolyl)methanes and pyrazolopyranopyrimidines in solvent-free conditions. In both synthetic protocols, the performance of this catalyst was very useful and general and presented attractive features including short reaction times with high yields, reasonable turnover frequency and turnover number values, easy workup, high performance under mild conditions, recoverability and reusability in 5 consecutive runs without losing activity. In addition, the antioxidant, antibacterial, and antifungal activity of some synthesized derivatives was studied for the first time. Our investigations showed that most of the studied compounds (2a, 5a, 8a, 11a, 2b and 5b–9b) have the mentioned biological properties. Graphical abstract