Myoepitheliomas are rare benign and malignant neoplasms composed of spindled, ovoid, or plasmacytoid cells. These tumors have been reported to occur in salivary glands and cutaneous, subcutaneous, and deep soft tissues of the head and neck, upper and lower extremities lung, and breast. Surgical resection with clear margins is the standard of care for the treatment of both low-and high-grade neoplasms. A 55- year-old female with no significant past medical history presented to an urgent care center with left ankle pain after suffering an inversion ankle sprain. Radiographs of the left ankle were reviewed and were negative for any bony pathology. She continued to have pain, edema, and developed a localized soft tissue mass at the retromalleolar area. MRI showed a soft tissue tumor adjacent to the peroneal tendons. The mass was removed and pathology confirmed it as a myoepithelioma, which is a rare tumor of the lower extremity. Myoepitheliomas are most commonly found in the salivary glands and can have a benign or malignant characteristic. Other common locations include the limbs and trunk region and the lesion typically presents in young to middle aged adults. Recurrence of histologically benign tumors has been associated with a local recurrence of 20% and rarely metastasize. Gene rearrangement at the ESWR1 (22q12) location is seen in >90% of soft tissue sarcomas. In this case, FISH analysis did not reveal gene rearrangement at ESWR1 22q12. The clinical significance is unknown and does not rule out a malignancy or other genetic changes.