The near equimolar and non-equimolar high entropy alloys (HEAs) having five or more major components along with their mingled sites over the surface have made them unique materials for various catalytic reactions involving renewable energies. HEAs provide a platform to tune the surface microstructure and chemistry by selecting and controlling the elements, opening up vistas to design new materials for catalysis. The present perspective aims to provide the correlation between HEAs' structure and catalytic performance in various applications with views on challenges and unique opportunities. The scientific and technological curiosity needs to dig deep into the multicomponent phase space to discover various new materials with unique catalytic properties. Display omitted •HEAs provide a platform to tune the surface microstructure and chemistry by selecting and controlling the elements, opening up vistas to design new materials for catalysis.•The present perspective aims to provide the correlation between the structure and catalytic performance of HEAs in various applications with views on challenges and unique opportunities.•The scientific and technological curiosity needs to dig deep into the multicomponent phase space to discover various new materials with unique catalytic properties.