E-viri
Recenzirano
-
Li, Yong; Liu, Yun-Bao; Zhang, Jian-Jun; Liu, Yang; Ma, Shuang-Gang; Qu, Jing; Lv, Hai-Ning; Yu, Shi-Shan
Journal of natural products (Washington, D.C.), 12/2015, Letnik: 78, Številka: 12Journal Article
Nine new grayanoids (1–9), together with 11 known compounds, were isolated from the roots of Rhododendron molle. The structures of the new compounds (1–9) were determined on the basis of spectroscopic analysis, including HRESIMS, and 1D and 2D NMR data. Compounds 4, 6, 12, and 14–20 showed significant antinociceptive activities in an acetic acid-induced writhing test. In particular, 14 and 15 were found to be more potent than morphine for both acute and inflammatory pain models and 100-fold more potent than gabapentin in a diabetic neuropathic pain model.
