The full manipulation of intrinsic properties of electromagnetic waves has become the central target in various modern optical technologies. Optical metasurfaces have been suggested for a complete control of light–matter interaction with subwavelength structures, and they have been explored widely in the past decade for creating next-generation multifunctional flat-optics devices. The current studies of metasurfaces have reached a mature stage where common materials, basic optical physics, and conventional engineering tools have been explored extensively for various applications such as light bending, metalenses, metaholograms, and many others. A natural question is where the future research on metasurfaces will be going: Quo vadis, metasurfaces? In this Mini Review, we provide perspectives on the future developments of optical metasurfaces. Specifically, we highlight recent progresses on hybrid metasurfaces employing low-dimensional materials and discuss biomedical, computational, and quantum applications of metasurfaces, followed by discussions of challenges and foreseeing the future of metasurface physics and engineering.