•A finite element model was developed to explain the causes of the rupture behavior transition of the Wenchuan earthquake.•The auxiliary stress regime transitioned from SH>Sh>Sv in the southwestern segment to SH>Sv>Sh in the northeastern segment.•The stress change associated with the significant first subevent reached 1.0 MPa.•Initial stress and stress change jointly controlled the northeastward rupture of the Mw7.9 Wenchuan earthquake. The rupture process of the Wenchuan earthquake demonstrated a transition from thrust-dominated slip to northeastward strike-slip motion along the Longmen Shan Fault Zone. The initial stress has been reported as playing a critical role in this process; however, the stress changes, especially those caused by the significant first subevent of the Wenchuan earthquake are not well understood. Here, we employ a three-dimensional finite element model of the Sichuan-Yunnan region to analyze the stress change caused by the significant first subevent and explore the possible influence on the following ruptures. The results indicate that the auxiliary maximum principal compressive stress (SH) associated with the significant first subevent was horizontal and that the auxiliary stress regime was SH>Sh>Sv, supporting the ongoing regional thrust motion near the southwestern segment of the rupture plane. However, in the northeastern segment, the auxiliary stress regime transitioned to SH>Sv>Sh, demonstrating that the stress changes promoted the transition of the rupture behavior from predominantly thrust motion in the southwest to right-lateral strike-slip motion in the northeastern segment, which was also supported by the dominant shear stress change and the subtle normal stress change along the fault plane in the northeastern segment. In addition, our modeled results also indicate that the orientation of the maximum principal compressive stress changed from SEE to northeastward NEE along the strike of Longmen Shan Fault Zone. This anticlockwise rotation hastened the rupture behavior transition, suggesting that both the initial stress and the stress changes associated with the first subevent jointly controlled the following northeastward rupture of the Mw7.9 Wenchuan earthquake.