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Muguruma, Kyohei; Pradipta, Ambara R.; Ode, Yudai; Terashima, Kazuki; Michiba, Hiroyuki; Fujii, Motoko; Tanaka, Katsunori
Bioorganic & medicinal chemistry, 12/2020, Letnik: 28, Številka: 24Journal Article
Display omitted Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy.
