•PDT used as a combine method for cases with invasive cervical cancer.•Only three patients were treated by combine chemo-PDT.•If it possible, precancerous lesions should be treated by thermal ablation.•Patients screened positive with HR-HPV or VIA or HR-HPV followed VIA, WHO recommends applies thermal ablation or cryotherapy.•Full examination should be provided to detect HPV infection or precancerous lesions.•Estimation of five-year relapse-free period.•Invasive surgical procedures cannot provide HPV elimination.•HPV recurrences is the main factor of relapse. The aim of this article is a retrospective analysis of PDT effectiveness in the treatment in early-stage cervical cancer and also analysis of HPV elimination via PDT A total of 28 patients were analyzed retrospectively, all with PDT treatment for early-stage cervical cancer. Patients underwent one PDT session or a multi-course PDT approach. This depended on individual reaction and response to therapy after the first session. A multi-course approach was performed over two months. Treatments were performed from 2015 to 2020. Relapse-free probability was assessed for these patients by Kaplan Meier estimator at 60 months and HPV elimiantion was also examined.. HPV elimination was in 82% of cases in three-month period after PDT (R2 = 0.71). Among the analyzed cases, full HPV elimination was detected in more than 90% of cases. Relapse-free probability from cervical cancer is 0,8 (CI95%: 0,53–1) at 60 months. Patients had mild (35.7%) and severe (28.6%) leucocyte reactions after PDT in three months. The article demonstrates treatment results for CC and detected a five-year period relapse-free probability after PDT. Patients completing a multi-treatment PDT protocol for invasive cervical cancer can achieve both high response rate and relapse-free survival.