To improve the mechanical properties and to reduce the water sorption amount of denture base resins, the polymerization characteristics of three novel fluoro-substituted monomers (MAF-TBN, MAF-MAE, MAF-TBN) and three styrene-type monomers (PTBS, PEES, PACS) were studied, as well as the copolymerization of these monomers with MMA. Subsequently, the mechanical properties and water sorption of the copolymers prepared from these monomers and MMA were evaluated. The polymerization reactivity of the monomers by BPO was lower than MMA, except for PACS. However, the copolymerization reactivity of the monomers with MMA was good, except for MAF-TBN. The copolymer of MAF-MAE and MMA in three fluoro-substituted monomers and PACS and MMA in three styrene-type monomers showed similar mechanical properties and extremely low water sorption compared with those of PMMA.