All-inorganic CsPbIxBr3−x (0 ≤x ≤ 3) perovskites are expected to fundamentally solve the thermal stability issue of perovskite solar cell toward its final commercialization. However, the humidity stability of this class of all-inorganic perovskite is still not intrinsically tackled out. Herein, aminoquinoline is introduced to construct a thus far unreported one-dimensional (1D) perovskite, in which the distorted PbI64- octahedra display a shoulder-by-shoulder arrangement along the 001 direction, and A-site quinoline (Aq) organic groups with π-π conjugate structure orderly distribute among the octahedra space. The structural incorporation of 1D Aq-PbI3(II) perovskite inside 3D CsPbI2Br perovskite is proved to be capable of improving the carrier transport ability, whilst enhancing its hydrophobic performances, which is associated with the unique structure of 1D Aq-PbI3(II) and lattice-matching heterojunction in 1D–3D perovskite. Consequently, the as-fabricated 1D–3D hybrid CsPbI2Br perovskite solar cell allows to increase the device VOC by a factor of 12%, yielding a power conversion efficiency (PCE) as high as 16.1%. Equally importantly, the corresponding 1D–3D perovskite solar cells demonstrate remarkably high stability more than 1300 h in comparison to the control 3D CsPbI2Br perovskite solar cell. This study provides a new strategy for the rational structure design of 1D–3D hybrid perovskite with high PCE and stability. Display omitted •Incorporation of quinoline group in A-site remarkably improves the high hydrophobic performance of CsPbI2Br perovskite.•The π-π conjugate structure in A-site enhances the charge-carrier transport ability.•The as-fabricated 1D–3D hybrid CsPbI2Br perovskite solar cell yields a power conversion efficiency as high as 16.1%.•1D–3D perovskite solar cells remain 86% PCE in 1300 h in ambient environment (H.R.=30%, T = 25 °C).