Aktivnost javnozdravstvene službe u Slavonskom Brodu započinje već u vrijeme Vojne granice, kada je organiziran sanitarni kordon i karantena da bi se spriječilo prenošenje opasnih zaraznih bolesti preko Save. Ipak, razvijenija preventivna djelatnost slijedila je u vrijeme djelovanja Andrije Štampara, jer se osniva Školska poliklinika, održavaju javnozdravstvena predavanja, započinje rad Antituberkuloznoga dispanzera, Ambulante protiv veneričnih bolesti te Stanice protiv bjesnoće. Velik je napredak učinjen 1946. godine osnivanjem Sanitarno-epidemiološke stanice kao zasebne institucije. Pokazala se vrlo uspješnom u suzbijanju poslijeratne epidemije trbušnoga tifusa, eradikaciji malarije i uvođenju masovnoga cijepljenja protiv dječjih zaraznih bolesti. Kroz četrdesetgodišnje razdoblje, u okviru Medicinskoga centra slijedila je izvjesna stagnacija, napose u usporedbi s velikim progresom kliničkih i dijagnostičkih grana medicine. Osnivanjem Županijskog zavoda za javno zdravstvo 1994. godine preventivna djelatnost doživljava znatni razvitak. To se posebno odnosi na praćenje i suzbijanje kroničnih degenerativnih bolesti, malignih tumora, zaštitu školske djece i mladeži, kao i na osvješćivanje sve češće prisutne bolesti ovisnosti u mladoj populaciji. The activities of the public health service in Slavonski Brod began already at the time of the Military Border, when a cordon sanitaire and quarantine were established to prevent the transmission of dangerous infectious diseases across the Sava River. However, a more developed form of preventive medicine was introduced during the time of Andrija Štampar, involving the establishment of the School Polyclinic, the holding of public health lectures, and the founding of the Anti-Tuberculosis Dispensary, the Anti-Venereal Clinic, and the Anti-Rabies Station. A major advance was made in 1946, when the Sanitary-Epidemiological Station was established as a separate institution. It proved very successful in combating the post-war epidemic of abdominal typhus, eradicating malaria, and introducing mass vaccination against children’s infectious diseases. A sort of stagnation followed during the 40-year period within the frame of the Medical Centre, especially when compared to the great progress of clinical and diagnostic medicine. Preventive activity developed significantly after the founding of the County Institute of Public Health in 1994. This is particularly applicable to the monitoring and combating of chronic degenerative diseases, malign tumours, protection of schoolchildren and youths, and increasing attention given to addictive disorders among the younger population.