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Wiesinger, Florian; Weidl, Eliane; Menzel, Marion I.; Janich, Martin A.; Khegai, Oleksandr; Glaser, Steffen J.; Haase, Axel; Schwaiger, Markus; Schulte, Rolf F.
Magnetic resonance in medicine, July 2012, Letnik: 68, Številka: 1Journal Article
Metabolic imaging with hyperpolarized 1‐13Cpyruvate offers the unique opportunity for a minimally invasive detection of cellular metabolism. Efficient and robust acquisition and reconstruction techniques are required for capturing the wealth of information present for the limited duration of the hyperpolarized state (∼1 min). In this study, the Dixon/IDEAL type of water–fat separation is expanded toward spectroscopic imaging of 1‐13Cpyruvate and its down‐stream metabolites. For this purpose, the spectral–spatial encoding is based on single‐shot spiral image encoding and echo‐time shifting in between excitations for the chemical‐shift encoding. In addition, also a free‐induction decay spectrum is acquired and the obtained chemical‐shift prior knowledge is efficiently used in the reconstruction. The spectral–spatial reconstruction problem is found to efficiently separate into a chemical‐shift inversion followed by a spatial reconstruction. The method is successfully demonstrated for dynamic, multislice 1‐13Cpyruvate metabolic MR imaging in phantom and in vivo rat experiments. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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