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Rothenberg, Mace L.; Liu, P.Y.; Wilczynski, Sharon; Nahhas, William A.; Winakur, Gaye L.; Jiang, Caroline S.; Moinpour, Carol M.; Lyons, Ben; Weiss, Geoffrey R.; Essell, James H.; Smith, Harriet O.; Markman, Maurie; Alberts, David S.
Gynecologic oncology, 12/2004, Letnik: 95, Številka: 3Journal Article
To assess the activity of vinorelbine in women with recurrent or resistant epithelial ovarian cancer following treatment with platinum and paclitaxel in terms of survival rate at 6 months, objective response rate (in the subset of patients with bidimensionally measurable disease), and health-related quality of life. Seventy-nine evaluable patients with progressive ovarian cancer following platinum and taxane therapy received vinorelbine 30 mg/m 2 days 1 and 8 of a 21-day treatment cycle. Six-month survival rate for the entire group was 65% (95% CI: 54–75%) and median survival was 10.1 months (95% CI: 7.7–13.6 months). In the 71 women with measurable disease, 0 complete and 2 partial responses were observed (RR = 3%) (95% CI: 0.3–10%). Patients reported substantial symptom-related distress at baseline, which persisted, but did not worsen, during treatment. Patients also had impaired physical functioning at baseline and this continued to decline during treatment. The 6-month survival rate achieved with salvage vinorelbine is comparable to the results obtained with other salvage therapies in patients with relapsed ovarian cancer. During the initial 10 weeks of treatment, vinorelbine did not appear to be effective in alleviating the symptom-related distress or progressive impairment of physical functioning associated with this disease.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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