The radiated noise of the centrifugal pump acts as a disturbance in many applications. The radiated noise is closely related to the hydraulic design. The hydraulic parameters in the multistage pump are complex and the flow interaction among different stages is very strong, which in turn causes vibration and noise problems because of the strong hydraulic excitation. Hence, the mechanism of radiated noise and its relationship with hydraulics must be studied clearly. In order to find the regular pattern of the radiated noise at different operational conditions, a hybrid numerical method was proposed to obtain the flow-induced noise source based on Lighthill acoustic analogy theory, which divided the computational process into two parts: computational fluid dynamics (CFD) and computational acoustics (CA). The unsteady flow field was solved by detached eddy simulation using the commercial CFD code. The detailed flow information near the surface of the vane diffusers and the calculated flow-induced noise source was extracted as the hydraulic exciting force, both of which were used as acoustic sources for radiated noise simulation. The acoustic simulation employed the finite element method code to get the sound pressure level (SPL), frequency response, directivity, et al. results. The experiment was performed inside a semi-anechoic room with a closed type pump test rig. The pump performance and acoustic parameters of the multistage pump at different flow rates were gathered to verify the numerical methods. The computational and experimental results both reveal that the radiated noise exhibits a typical dipole characteristic behavior and its directivity varies with the flowrate. In addition, the sound pressure level (SPL) of the radiated noise fluctuates with the increment of the flow rate and the lowest SPL is generated at 0.8Qd, which corresponds to the maximum efficiency working conditions. Furthermore, the experiment detects that the sound pressure level of the radiated noise in the multistage pump rises linearly with the increase of the rotational speed. Finally, an example of a low noise pump design is processed based on the obtained noise characteristics.