The evolution of microstructure and crystallographic texture during thermo-mechanical processing and their effect on tensile behavior of Al-Cu-Li (AA2195) alloy were investigated in the present work. The initial hot rolled sheets were cold rolled by unidirectional rolling and cross-rolling. These sheets were annealed and imparted T6 (solution treatment + water quenching + aging) temper. Uni-directionally rolled samples exhibited typical copper texture which subsequently transformed to cube component after thermal treatment whereas, the cross-rolled sample exhibited brass texture which subsequently weakened upon thermal treatment. The difference in the precipitation characteristics resulted in transition from anisotropic to isotropic strength in cross rolled samples in heat treated condition. The strength anisotropy has been explained based on the average precipitation strengthening factor and accommodation tensor.