E-viri
Recenzirano
-
Wei, Peiran; Xu, Yan; Zhang, Huikang; Wang, Liming
Chemical engineering journal (Lausanne, Switzerland : 1996), 10/2021, Letnik: 422Journal Article
•We have successfully fabricated the insulin-PLGA/PDA/PCL composite scaffolds.•The scaffolds can provide a slow, sustained release of insulin.•The scaffolds stimulated chondrocytes proliferation and BMSCs differentiation.•The scaffolds enhanced bone and cartilage repair in vivo. Due to the poor ability of self-repair and regeneration, articular cartilage and subchondral bone defects and degradation are still a big problem nowadays. The aim of the present study is to fabricate and investigate a 3D printed polycaprolactone (PCL) scaffold modified by insulin-releasing PLGA nanoparticles for osteochondral repair. The double-emulsion solvent evaporation method is used to fabricate the insulin-coated PLGA nanoparticles, and the physicochemical characterization of the nanoparticles and scaffolds are tested. The cell studies in vitro and animal experiments in vivo are also investigated. The results show the hydrophilicity of the scaffolds is highly improved when coated with polydopamine (PDA), and the insulin release curve of the insulin-PLGA/PDA/PCL scaffolds exhibit a slowly and sustained profile after an initial burst release. The in vitro studies show that the insulin-PLGA/PDA/PCL scaffolds significantly improve the osteogenic differentiation of rabbit bone mesenchymal stem cells (rBMSCs) and the proliferation of chondrocytes. And the in vivo studies show that the insulin-PLGA/PDA/PCL scaffolds significantly improve repair of cartilage and subchondral bone after 8- and 12-week implantation in rabbit osteochondral defects. These findings exhibit that the insulin-PLGA/PDA/PCL scaffolds can provide a slowly, sustained release of insulin and may be a promising strategy for osteochondral repair.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.