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Marx, Grace E; Biggerstaff, Brad J; Nawrocki, Courtney C; Totten, Sarah E; Travanty, Emily A; Burakoff, Alexis W; Scott, Tracy; De Hey, Jesse Chavez-Van; Carlson, Jesse J; Wendel, Karen A; Harcourt, Jennifer L; Tamin, Azaibi; Thomas, Jennifer D; Rowan, Sarah E; Matzinger, Shannon R; Hudziec, Meghan; Hetherington-Rauth, Molly C; Pysnack, Nicholas J; Delmonico, Christopher; Huynh-Templeman, Kimberly; Stitzlein, Tara M; Rossheim, Alexandria E B; Folster, Jennifer; Medrzycki, Magdalena; Wong, Phili; Jain, Shilpi; Thornburg, Natalie
Clinical infectious diseases, 07/2021, Letnik: 73, Številka: Supplement_1Journal Article
Abstract Background Nasopharyngeal specimens (NPS) are commonly used for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing but can be uncomfortable for patients. Self-collected saliva specimens (SS) or anterior nasal specimens (ANS) for SARS-CoV-2 detection are less invasive, but the sensitivity of these specimen types has not been thoroughly evaluated. Methods During September–November 2020, 730 adults undergoing SARS-CoV-2 testing at community testing events and homeless shelters in Denver provided self-collected SS and ANS before NPS collection and answered a short survey about symptoms and specimen preference. Specimens were tested for SARS-CoV-2 by means of real-time reverse-transcription polymerase chain reaction (rRT-PCR); viral culture was performed on a subset of specimens positive by rRT-PCR. The sensitivity of SS and ANS for SARS-CoV-2 detection by rRT-PCR was measured against that of NPS. Subgroup analyses included test outcomes by symptom status and culture results. Results Sensitivity for SARS-CoV-2 detection by rRT-PCR appeared higher for SS than for ANS (85% vs 80%) and higher among symptomatic participants than among those without symptoms (94% vs 29% for SS; 87% vs 50% for ANS). Among participants with culture-positive SARS-CoV-2 by any specimen type, the sensitivities of SS and ANS by rRT-PCR were 94% and 100%, respectively. SS and ANS were equally preferred by participants; most would undergo NPS collection again despite this method’s being the least preferred. Conclusions SS were slightly more sensitive than ANS for SARS-CoV-2 detection with rRT-PCR. With both SS and ANS, SARS-CoV-2 was reliably detected among participants with symptoms. Self-collected SS and ANS offer practical advantages, are preferred by patients, and might be most useful for testing people with coronavirus disease 2019 symptoms.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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