E-viri
Recenzirano
Odprti dostop
-
de Groot, Mark C. H.; Candore, Gianmario; Uddin, Md. Jamal; Souverein, Patrick C.; Ali, M. Sanni; Belitser, Svetlana V.; Huerta, Consuelo; Groenwold, Rolf H. H.; Alvarez, Yolanda; Slattery, Jim; Korevaar, Joke; Hoes, Arno W.; Roes, Kit C. B.; de Boer, Anthonius; Douglas, Ian J.; Schlienger, Raymond G.; Reynolds, Robert; Klungel, Olaf H.; Gardarsdottir, Helga
Pharmacoepidemiology and drug safety, 03/2016, Letnik: 25, Številka: S1Journal Article
Purpose The purpose of this study is to evaluate the performance and validity of the case‐crossover (CCO) and self‐controlled case‐series (SCCS) designs when studying the association between hip/femur fracture (HF) and antidepressant (AD) use in general practitioner databases. In addition, comparability with cohort and case–control designs is discussed. Methods Adult patients with HF and who received an AD prescription during 2001–2009 were identified from UK's The Health Improvement Network (THIN) and the Dutch Mondriaan databases. AD exposure was classified into current, recent and past/non‐use (reference). In the CCO, for each patient, a case moment (date of HF) and four prior control moments at −91, −182, −273 and −365 days were defined. In SCCS, incidence of HF was compared between exposure states. Conditional logistic regression was used in the CCO and Poisson regression in the SCCS to compute odds ratios and incidence rate ratios, respectively. In CCO, we adjusted for time‐varying co‐medication and in SCCS for age. Results Adjusted estimates for the effect of current AD exposure on HF were higher in the CCO (co‐medication‐adjusted odds ratio, THIN: 2.24, 95% confidence interval CI: 2.04–2.47; Mondriaan: 2.57, 95%CI 1.50, 4.43) than in the SCCS (age‐adjusted incidence rate ratio, THIN: 1.41, 95%CI 1.32, 1.49; Mondriaan: 2.14, 95%CI 1.51, 3.03). The latter were comparable with the traditional designs. Conclusion Case‐only designs confirmed the association between AD and HF. The CCO design violated assumptions in this study with regard to exchangeability and length of exposure, and transient effects on outcome. The SCCS seems to be an appropriate design for assessing AD–HF association. Copyright © 2016 John Wiley & Sons, Ltd.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.