Background More than one third of Covid‐19 patients at the time of discharge from hospitalization have evidence of cognitive impairment and motor deficits. Patients surviving COVID‐19 are at high risk for subsequent development of neurological disease, particularly Alzheimer’s disease. Method The clinical Phase 2/3 evaluates the safety and efficacy of NA‐831 alone, and a combination therapy comprises NA‐831 with an anti‐viral drug Atazanavir, NA‐831 with an anti‐inflammatory drug, and a potential synergy between Atazanavir and Dexamethasone. The Clinical Protocol: Study Type: Interventional Phase 2/3 Estimated Enrollment: 525 participants Allocation: Randomized There will be daily symptom surveys for 14 days, then weekly thereafter for 3 weeks resulting in a total duration of follow up of 36 days. Status: is recruiting and the study is expected to be completed by December 15, 2023 Result Primary Outcome Measures Time from randomization to recovery defined as 1) absence of fever, as defined as at least 48 hours since last temperature ≥ 38.0°C without the use of fever‐reducing medications 2) absence of symptoms of greater than mild severity for 24 hours 3) not requiring supplemental oxygen beyond pre‐COVID baseline AND 4) freedom from mechanical ventilation or death Secondary Outcome Measures 1) Brief Cognitive Rating Scale (BCRS) and 2) Clinician’s Interview‐Based Impression of Change plus caregiver input (CIBIC‐plus) after 24 weeks. Conclusion The progress of the clinical trials will be presented discussed.