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  • Discovery of thiophene-2-ca...
    Chan, Laval; Das, Sanjoy K.; Reddy, T.Jagadeeswar; Poisson, Carl; Proulx, Mélanie; Pereira, Oswy; Courchesne, Marc; Roy, Caroline; Wang, Wuyi; Siddiqui, Arshad; Yannopoulos, Constantin G.; Nguyen-Ba, Nghe; Labrecque, Denis; Bethell, Richard; Hamel, Martine; Courtemanche-Asselin, Philippe; L'Heureux, Lucille; David, Maud; Nicolas, Olivier; Brunette, Stéphanie; Bilimoria, Darius; Bédard, Jean

    Bioorganic & medicinal chemistry letters, 02/2004, Letnik: 14, Številka: 3
    Journal Article

    The discovery of a novel class of HCV NS5B polymerase inhibitors, 3-arylsulfonylamino-5-phenyl-thiophene-2-carboxylic acids is described. SAR studies have yielded several potent inhibitors of HCV polymerase as well as of HCV subgenomic RNA replication in Huh-7 cells. Graphic