Purpose of Review To describe recent advances in infection prevention strategies for penile prosthesis surgery. Recent Findings Improvements in surgical technique, antibiotic prophylaxis, prosthetic device design, and patient selection have globally reduced penile prosthesis infection rates. However, current societal antibiotic prophylaxis guidelines may fail to cover all organisms implicated in penile prosthesis infections, particularly fungal and anaerobic pathogens. Summary Although significant strides have been made in reducing penile prosthesis infections, further education and research efforts are needed to continue to prevent this infrequent, but devastating complication. This review discusses recent advances in penile infection understanding and prevention.