E-viri
PDF
Recenzirano
Odprti dostop
-
Löffler, Dennis; Brocke-Heidrich, Katja; Pfeifer, Gabriele; Stocsits, Claudia; Hackermüller, Jörg; Kretzschmar, Antje K.; Burger, Renate; Gramatzki, Martin; Blumert, Conny; Bauer, Kay; Cvijic, Helena; Ullmann, A. Kerstin; Stadler, Peter F.; Horn, Friedemann
Blood, 08/2007, Letnik: 110, Številka: 4Journal Article
Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6–dependent survival and growth of multiple myeloma cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is controlled by an upstream enhancer containing 2 Stat3 binding sites strictly conserved since the first observed evolutionary appearance of miR-21 and Stat3. MiR-21 induction by IL-6 was strictly Stat3 dependent. Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3.
