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Ding, Jian; Li, Guo; Liu, Hejun; Liu, Lulu; Lin, Ying; Gao, Jingyan; Zhou, Guoqiang; Shen, Lingling; Zhao, Mengxi; Yu, Yanyan; Guo, Weihui; Hommel, Ulrich; Ottl, Johannes; Blank, Jutta; Aubin, Nicola; Wei, Yi; He, Hu; Sage, David R.; Atadja, Peter W.; Li, En; Jain, Rishi K.; Tallarico, John A.; Canham, Stephen M.; Chiang, Ying-Ling; Wang, He
ACS chemical biology, 01/2023, Letnik: 18, Številka: 1Journal Article
WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple processes. It is also a prominent target for pharmacological inhibition in diseases such as cancer, aging, and neurodegenerative disorders. Interactions between WDR5 and various partners are essential for sustaining its function. Most drug discovery efforts center on the WIN (WDR5 interaction motif) site of WDR5 that is responsible for the recruitment of WDR5 to chromatin. Here, we describe the discovery of novel WDR5 inhibitors for the other WBM (WDR5 binding motif) pocket on this scaffold protein, to disrupt WDR5 interaction with its binding partner MYC by high-throughput biochemical screening, subsequent molecule optimization, and biological assessment. These new WDR5 inhibitors provide useful probes for future investigations of WDR5 and an avenue for targeting WDR5 as a therapeutic strategy.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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