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Hollander, W. J.; Sonnenschein‐van der Voort, A. M. M.; Holster, I. L.; Jongste, J. C.; Jaddoe, V. W.; Hofman, A.; Perez‐Perez, G. I.; Moll, H. A.; Blaser, M. J.; Duijts, L.; Kuipers, E. J.
Alimentary pharmacology & therapeutics, April 2016, Letnik: 43, Številka: 8Journal Article
Summary Background Helicobacter pylori prevalence in Western countries has been declining simultaneously with increases in childhood asthma and allergic diseases; prior studies have linked these phenomena. Aims To examine the association between H. pylori colonisation in children and risk of asthma and related conditions at school age. We secondly examined additional effects of maternal H. pylori status by pairing with children's status. Methods This study was embedded in a multi‐ethnic population‐based cohort in Rotterdam, The Netherlands. We measured anti‐H. pylori and anti‐CagA antibodies in serum of children obtained at age 6 years, and of their mothers obtained during midpregnancy. Asthma or related conditions were reported for children at age 6 years. We used multivariate logistic regression analyses among 3797 subjects. Results In children, the H. pylori positivity rate was 8.7%, and 29.2% of these were CagA‐positive. A child's colonisation with a CagA‐negative‐H. pylori strain was associated with an increased risk of asthma (Odds ratio 2.11; 95% CI 1.23–3.60), but this differed for European (3.64; 1.97–6.73) and non‐European (0.52; 0.14–1.89) children. When taking into account maternal H. pylori status, only H. pylori‐positive children with an H. pylori‐negative mother had increased risk of asthma (2.42; 1.11–5.27), accounting for 3.4% of the asthma risk. Conclusions Colonisation of a European child with a CagA‐negative‐H. pylori strain at age 6 was associated with an increased prevalence of asthma, but there was no association for non‐European children. The underlying mechanisms for the observed risk differences require further research.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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