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Yoshida, Kiryu; Mizukami, Takuya; Fukagawa, Masafumi; Akizawa, Tadao; Morohoshi, Hokuto; Sambe, Takehiko; Ito, Hidetoshi; Ogata, Hiroaki; Uchida, Naoki
Clinical and experimental nephrology, 02/2023, Letnik: 27, Številka: 2Journal Article
Background It is necessary to re-examine the optimal phosphate (P) and calcium (Ca) target values in the contemporary management of chronic kidney disease–mineral and bone disorder to reduce the risks of cardiovascular events in patients receiving hemodialysis. Methods We performed a post-hoc analysis of the LANDMARK study. The outcomes were defined as cardiovascular events and all-cause death. Data from 2135 patients receiving hemodialysis at risk of vascular calcification were analyzed using a time-dependent Cox proportional hazard model adjusted for background factors. Results On the hazard ratio (HR) curve, the ranges where the lower 95% confidence interval (CI) were below the minimum of HR (= 1.00) were as follows: P = 3.5–5.5 mg/dL; albumin-adjusted Ca < 9.1 mg/dL for cardiovascular events; and P = 3.6–5.3 mg/dL; albumin-adjusted Ca < 9.1 mg/dL for all-cause mortality. In stratified analysis, the HRs for cardiovascular events in P < 3.5 mg/dL and P ≥ 5.5 mg/dL were similar to that of P = 3.5–5.5 mg/dL ( P ≥ 0.05), and albumin-adjusted Ca ≥ 9.1 mg/dL had higher HR than values < 9.1 mg/dL 1.30 (95% CI 1.00–1.68; P = 0.046). For all-cause mortality, the HR in P < 3.6 mg/dL was higher than that in P = 3.6–5.3 mg/dL 1.76 (95% CI 1.25–2.48; P = 0.001), while the HRs between P ≥ 5.3 mg/dL and P = 3.6–5.3 mg/dL as well as those between albumin-adjusted Ca ≥ 9.1 and < 9.1 mg/dL were not significantly different ( P ≥ 0.05). Conclusions Managing albumin-adjusted Ca < 9.1 mg/dL may reduce the cardiovascular risk among patients undergoing hemodialysis. Hypophosphatemia < 3.6 mg/dL may be associated with mortality.
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